Table of Contents

APSC Answer Writing (Daily) based on Assam Tribune – 18/07/2025

For APSC CCE and other Assam Competitive examinations aspirants, practicing Daily Answer Writing is vital. This blog covers the most important Main question and its model Answer from the Assam Tribune today (18-07-2025).

❓ Question:

Discuss the significance of India’s first human trial of a Dengue DNA vaccine in the context of public health innovation. What are the challenges associated with vaccine development for vector-borne diseases like dengue in India?
(Word Limit: 250)

✅ Model Answer:

🔸 Introduction
Vector-borne diseases like dengue, transmitted by the Aedes aegypti mosquito, remain a persistent public health challenge in India. The recent launch of India’s first human trial of a Dengue DNA vaccine at Assam Medical College, coordinated by ICMR and NEIGRIHMS, marks a pivotal moment in the country’s fight against this climate-sensitive disease.

🔹 Significance of Dengue DNA Vaccine Trial

Aspect	Relevance
Biotech Advancement	First use of DNA-based technology against dengue in India, following success in COVID-19 (ZyCoV-D)
Region-Specific Research	Conducted in Assam, a high-burden state, ensuring local epidemiological relevance
Public Health Preparedness	Builds long-term immunity, supports vector control gaps
Global Health Contribution	Aligns with WHO’s push for effective dengue vaccine development

🔹 Challenges in Dengue Vaccine Development

Challenge	Description
Serotype Complexity	Dengue has 4 distinct serotypes; vaccine must cover all without causing antibody-dependent enhancement
Vaccine Hesitancy	New platforms like DNA vaccines may face public mistrust
Cold Chain Logistics	Ensuring safe storage in remote and hilly areas like Northeast India
Long Trial Timelines	Phases II and III required for efficacy and safety, delaying rollout
Co-infection Risks	Dengue often overlaps with JE or malaria, complicating diagnosis and vaccine trials

🔸 Conclusion
The DNA vaccine trial for dengue symbolizes India’s science-led health sovereignty, especially in underserved regions like the Northeast. However, its success hinges on a multi-pronged approach—scientific rigor, policy support, community engagement, and robust healthcare infrastructure.

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