APSC Answer Writing (Daily) based on Assam Tribune – 18/07/2025
For APSC CCE and other Assam Competitive examinations aspirants, practicing Daily Answer Writing is vital. This blog covers the most important Main question and its model Answer from the Assam Tribune today (18-07-2025).
Question
Discuss the significance of India’s first human trial of a Dengue DNA vaccine in the context of public health innovation. What are the challenges associated with vaccine development for vector-borne diseases like dengue in India?
(Word Limit: 250)
Model Answer
🔸 Introduction
Vector-borne diseases like dengue, transmitted by the Aedes aegypti mosquito, remain a persistent public health challenge in India. The recent launch of India’s first human trial of a Dengue DNA vaccine at Assam Medical College, coordinated by ICMR and NEIGRIHMS, marks a pivotal moment in the country’s fight against this climate-sensitive disease.
Significance of Dengue DNA Vaccine Trial
| Aspect | Relevance |
| Biotech Advancement | First use of DNA-based technology against dengue in India, following success in COVID-19 (ZyCoV-D) |
| Region-Specific Research | Conducted in Assam, a high-burden state, ensuring local epidemiological relevance |
| Public Health Preparedness | Builds long-term immunity, supports vector control gaps |
| Global Health Contribution | Aligns with WHO’s push for effective dengue vaccine development |
Challenges in Dengue Vaccine Development
| Challenge | Description |
| Serotype Complexity | Dengue has 4 distinct serotypes; vaccine must cover all without causing antibody-dependent enhancement |
| Vaccine Hesitancy | New platforms like DNA vaccines may face public mistrust |
| Cold Chain Logistics | Ensuring safe storage in remote and hilly areas like Northeast India |
| Long Trial Timelines | Phases II and III required for efficacy and safety, delaying rollout |
| Co-infection Risks | Dengue often overlaps with JE or malaria, complicating diagnosis and vaccine trials |
🔸 Conclusion
The DNA vaccine trial for dengue symbolizes India’s science-led health sovereignty, especially in underserved regions like the Northeast. However, its success hinges on a multi-pronged approach—scientific rigor, policy support, community engagement, and robust healthcare infrastructure.
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